Welcome to CSB

The capability of biological systems to respond to environmental changes is realized by a complex dynamic adjustment of the interplay between genes, proteins and metabolites. For a deeper understanding at the systems level, we need to study the structure and dynamics of cellular and organismal functions rather than the characteristics of isolated parts of a cell or an organism.

Research

What our research is aiming for

The main focus of our group is the application and development of computational methods to process and integrate quantitative biological data from modern high-throughput measurements in order to gain novel insights into biological responses to environment changes. The main challenge is the rigorous integration of different system level analyses and present knowledge into biological interpretable models. Therefore, we want to drive theory and technology forward with a combination of biological science, applied informatics, statistical and machine learning approaches.

Team

Our research team on CSB

Timo Mühlhaus (Junior Professor)

Timo Mühlhaus

Junior Professor
David Zimmer (PhD Student)

David Zimmer

PhD Student
Benedikt Venn (PhD Student)

Benedikt Venn

PhD Student
JO

Lukas Weil

PhD Student
JO

Oliver Maus

PhD Student
JO

Kevin Schneider

PhD Student
JO

Jonathan Ott

KF

Kevin Frey

Nn

none

  • 2020
    Lukas Weil (Master Student) Kevin Schneider (Master Student)
  • 2019
    Patrick Blume (Master Student) Marc Gottlieb (Bachelor Student)
  • 2018
    Benedikt Venn (Master Student) Esther Wieczorek (Master Student) Isabella Christina Capilla Navarro (Master Student)
  • 2017
    David Zimmer (Master Student) Kevin Schneider (Bachelor Student)
  • 2016
    Sabrina Gödel (Master Student)
    Lukas Weil (Bachelor Student)
  • 2015
    Esther Wieczorek (Bachelor Student)
    Paul Menges (Bachelor Student)

Publication

View our selected publications

Mol. Cell.
2020
The NADH Dehydrogenase Nde1 Executes Cell Death after Integrating Signals from Metabolism and Proteostasis on the Mitochondrial Surface
Saladi S, Boos F, Poglitsch M, Meyer H, Sommer F, Mühlhaus T, Schroda M, Schuldiner M, Madeo F, and Herrmann JM
J Neurochem.
2019
Poor transcript-protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause
Moritz CP, Mühlhaus T, Tenzer S, Schulenborg T, and Friauf E
Plant physiology
2019
The Role of Plastidic Trigger Factor Serving Protein Biogenesis in Green Algae and Land Plants
Rohr M, Ries F, Herkt C, Gotsmann VL, Westrich LD, Gries K, Trösch R, Christmann J, Chaux-Jukic F, Jung M, Zimmer D, Mühlhaus T, Sommer F, Schroda M, Keller S, Möhlmann T, Willmund F
18th ECC
2019
Curve form-based quantization of short time series data
Leifeld T, Venn B, Cui S, Zhang Z, Mühlhaus T*, Zhang P*
Biotechnol J.
2019
Metabolic engineering of Corynebacterium glutamicum for high-level ectoine production - design, combinatorial assembly and implementation of a transcriptionally balanced heterologous ectoine pathway
Gießelmann G, Dietrich D, Jungmann L, Kohlstedt M, Jeon E J, Yim SS, Sommer F, Zimmer D, Mühlhaus T, Schroda M, Jeong KJ, Becker J, Wittmann C
Plant Physiology
2019
The Chlamydomonas deg1c Mutant Accumulates Proteins Involved in High Light Acclimation
Theis J, Lang J, Spaniol B, Ferté S, Niemeyer J, Sommer F, Zimmer D, Venn B, Mehr SF, Mühlhaus T, Wollman F-A, Schroda M
J. Cell Biol.
2018
Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences
Backes S, Hess S, Boos F, Woellhaf M W, Gödel S, Jung M, Mühlhaus T*, and Herrmann J M*
Frontiers in Plant Science
2018
Absolute Quantification of Major Photosynthetic Protein Complexes in Chlamydomonas reinhardtii Using Quantification Concatamers (QconCATs)
Hammel A, Zimmer D, Sommer F, Mühlhaus T* and Schroda M*
BIO-PROTOCOL
2018
Detection of Internal Matrix Targeting Signal-like Sequences (iMTS-Ls) in Mitochondrial Precursor Proteins Using the TargetP Prediction Tool
Boos F*, Mühlhaus T*, and Herrmann J
New Phytologist
2018
Investigations on VELVET regulatory mutants confirm the role of host tissue acidification and secretion of proteins in the pathogenesis of Botrytis cinerea
Müller N, Leroch M, Schumacher J, Zimmer D, Könnel A, Klug K, Leisen T, Scheuring D, Sommer F, Mühlhaus T, Schroda M, and Hahn M
Nature PLANTS
2018
Commonalities and differences of chloroplast translation in a green alga and land plants
Trösch R, Barahimipour R, Gao Y, Badillo-Corona J A, Gotsmann V L, Zimmer D, Mühlhaus T, Zoschke R, and Willmund F
Plant molecular biology
2017
Substrates of the chloroplast small heat shock proteins 22E/F point to thermolability as a regulative switch for heat acclimation in Chlamydomonas reinhardtii
Rütgers M, Muranaka L S, Mühlhaus T, Sommer F, Thoms S, Schurig J, Willmund F, Schulz-Raffelt M, and Schroda M
Proceedings of the National Academy of Sciences of the United States of America
2016
A repeat protein links Rubisco to form the eukaryotic carbon-concentrating organelle
Mackinder L C M, Meyer M T, Mettler-Altmann T, Chen V K, Mitchell M C, Caspari O Freeman Rosenzweig E S, Pallesen L, Reeves G, Itakura A, Roth R, Sommer F, Geimer S, Mühlhaus T, Schroda M, Goodenough U, Stitt M, Griffiths H, Jonikas M C
Plant Physiology
2016
GUN1 controls accumulation of the plastid ribosomal protein S1 at the protein level and interacts with proteins involved in plastid protein homeostasis
Tadini L, Pesaresi P, Kleine T, Rossi F, Guljamow A, Sommer F, Mühlhaus T, Schroda M, Masiero S, Pribil M, Rothbart M, Hedtke B, Grimm B and Leister D
Nature PLANTS
2015
Identification of the transporter responsible for sucrose accumulation in sugar beet taproots
Jung B, Ludewig F, Schulz A, Meißner G, Wöstefeld N, Flügge U-I, Pommerrenig B, Wirsching P, Sauer N, Koch W, Sommer F, Mühlhaus T, Schroda M, Cuin TA, Graus D, Marten I, Hedrich R and Eckkehard HE
Biochimica et biophysica acta
2015
ATP-dependent molecular chaperones in plastids - More complex than expected
Trösch R, Mühlhaus T, Schroda M, and Willmund F
The Plant Cell
2014
Systems Analysis of the Response of Photosynthesis, Metabolism, and Growth to an Increase in Irradiance in the Photosynthetic Model Organism Chlamydomonas reinhardtii
Mettler T, Mühlhaus, T.*, Hemme D, Schöttler M-A, Rupprecht J, Idoine A, Veyel D, Pal S K, Yaneva-Roder L, and Winck F V, Sommer F, Vosloh D, Seiwert B, Erban A, Burgos A, Arvidsson S, Schönfelder S, Arnold A, Günther M, Krause U, Lohse M, Kopka J, Nikoloski Z, Mueller-Roeber B, Willmitzer L, Bock R, Schroda M and Stitt M
The Plant Cell
2014
Nitrogen-Sparing Mechanisms in Chlamydomonas Affect the Transcriptome, the Proteome, and Photosynthetic Metabolism
Schmollinger S*, Mühlhaus T*, Boyle N R*, Blaby I K, Casero D, Mettler T, Moseley J L, Kropat J, Sommer F, Strenkert D, Hemme D, Pellegrini M, Grossman RA, Stitt M, Schroda M and Merchant
The Plant Cell
2014
Conditional Depletion of the Chlamydomonas Chloroplast ClpP Protease Activates Nuclear Genes Involved in Autophagy and Plastid Protein Quality Control
Ramundo S, Casero D, Mühlhaus T, Hemme D, Sommer F, Crèvecoeur M, Rahire M, Schroda M, Rusch J, Goodenough U, Pellegrini M, Perez-Perez ME, Crespo JL, Schaad O, Civic N, Rochaix JD
Methods in molecular biology (Clifton, N.J.)
2014
Identification and validation of protein-protein interactions by combining co-immunoprecipitation, antigen competition, and stable isotope labeling
Sommer F, Mühlhaus T, Hemme D, Veyel D, and Schroda M
The Plant Cell
2012
Evidence for a role of VIPP1 in the structural organization of the photosynthetic apparatus in Chlamydomonas
Nordhues A, Schöttler M A, Unger A-K, Geimer S, Schönfelder S, Schmollinger S, Rütgers M, Finazzi G, Soppa B, Sommer F, Mühlhaus T, Roach T, Krieger-Liszkay A, Lokstein H, Crespo JL and Schroda M
Systembiologie.de
2010
Wie Pflanzen auf Umweltveränderungen reagieren
Hemme D*, Weiss J*, Mühlhaus T*, Sommer F, and Schroda M
International review of cell and molecular biology
2010
New insights into the roles of molecular chaperones in Chlamydomonas and Volvox
Nordhues A, Miller S M, Mühlhaus T, and Schroda M
Plant signaling & behavior
2009
A 'foldosome' in the chloroplast?
Schroda M, and Mühlhaus T
The Journal of biological chemistry
2008
Assistance for a chaperone: Chlamydomonas HEP2 activates plastidic HSP70B for cochaperone binding
Willmund F, Hinnenberger M, Nick S, Schulz-Raffelt M, Mühlhaus T, and Schroda M
The Journal of biological chemistry
2007
The NH2-terminal domain of the chloroplast GrpE homolog CGE1 is required for dimerization and cochaperone function in vivo
Willmund F, Mühlhaus T*, Wojciechowska M, and Schroda M

Open Source

Take a look on our public repositories on github. Feel free to contribute!

View Github

Contact

Faculty Impressum Datenschutz

Jun. Prof. Dr. Timo Mühlhaus
Computational Systems Biology

University of Kaiserslautern
Paul-Ehrlich-Str. 23 R109
67663 Kaiserslautern, Germany

+ 49 631 205 4657
+ 49 631 205 2999